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Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

《工程管理前沿（英文）》 2016年 第3卷 第1期   页码 30-38 doi: 10.15302/J-FEM-2016008

摘要： Frequent traffic accidents constitute a major danger to human beings. The accident-prone driver who has the stable physiological, psychological, and behavioral characteristics is one of the most prominent causes of traffic accidents. The internal link between the individual characteristics and the accident proneness has been a difficult point in the accident prevention research. The authors selected accident-prone drivers as cases and safe drivers as controls (case-control group) from 18,360 drivers who were enrolled from three public transportation incorporations of China using area stratified sampling method. The case-control groups were 1:1 matched. The authors performed genome-wide association study (GWAS) by 179 cases and 179 controls using the U.S. Affymetrix Genome-Wide Human Mapping SNP 6.0 Array. The authors observed that the gene frequencies of 34 single-nucleotide polymorphisms (SNPs) in three regions of cases were higher than those in the control ( <10 ). The authors then tested two independent replication sets for strong association 6 SNPs in 349 pairs of case-control drivers using the U.S. ABI 3730 sequencing method. The results indicated that SNP rs6069499 within linked CBLN4 gene are strongly associated with accident proneness ( =6.37×10 ). According to CBLN4 gene mainly involved in adrenal development and the regulation of secretion, the authors performed 12 biochemical parameters of the blood using radioimmunoassay. The levels of dopamine (DA) and adrenocorticotropic (ACTH) hormone showed significant differences between accident-prone drivers and safe drivers ( =0.03, =0.01). It is suggested that the accident-prone drivers may have the idiosyncrasy of susceptibility.

关键词： accident proneness     genome-wide association study (GWAS)     dopamine (DA)     ACTH     susceptibility gene     traffic accident epidemiology     accident prevention     traffic safety     three-dimensional model    

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Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

null

《医学前沿（英文）》 2018年 第12卷 第1期   页码 76-83 doi: 10.1007/s11684-017-0609-5

摘要：

Tuberculosis (TB) has remained an ongoing concern in China. The national scale-up of the Directly Observed Treatment, Short Course (DOTS) program has accelerated the fight against TB in China. Nevertheless, many challenges still remain, including the spread of drug-resistant strains, high disease burden in rural areas, and enormous rural-to-urban migrations. Whether incident active TB represents recent transmission or endogenous reactivation has helped to prioritize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of ( ) strains in many settings. However, the transmission patterns of TB in most areas of China are still not clear. Studies carried out to date could not capture the real burden of recent transmission of the disease in China because of the retrospective study design, incomplete sampling, and use of low-resolution genotyping methods. We reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden due to recent transmission of strains, the primary transmission of drug-resistant TB, and the evaluation of a feasible genotyping method of strains in circulation.

关键词： tuberculosis     recent transmission     molecular epidemiology     China    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

null

《医学前沿（英文）》 2014年 第8卷 第2期   页码 135-144 doi: 10.1007/s11684-014-0331-5

摘要：

Chronic hepatitis B is a major health problem in China. The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection in China from highly to moderately endemic. The most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in western provinces are genotypes D and C/D hybrid. Chronic hepatitis B poses a heavy burden to the society in China. Different treatment strategies have been explored to improve patient outcomes in a cost-effective manner. However, antiviral drugs with a low genetic barrier to resistance are still extensively used because of the generally low income and limited resources in China. Individualized antiviral therapy is closely associated with translational medicine, which utilizes information from studies on genomics, immune biomarkers, and fibrosis. The results of these studies are crucial in further improving treatment outcomes.

关键词： chronic hepatitis B     epidemiology     prevention     treatment    

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

《医学前沿（英文）》 2020年 第14卷 第1期   页码 1-7 doi: 10.1007/s11684-019-0733-5

摘要： With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

关键词： molecular epidemiology     norovirus     disease burden     genotype     China    

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Multi-class dynamic network traffic flow propagation model with physical queues

Yanfeng LI, Jun LI

《工程管理前沿（英文）》 2017年 第4卷 第4期   页码 399-407 doi: 10.15302/J-FEM-2017041

摘要： This paper proposes an improved multi-class dynamic network traffic flow propagation model with a consideration of physical queues. Each link is divided into two areas: Free flow area and queue area. The vehicles of the same class are assumed to satisfy the first-in-first-out (FIFO) principle on the whole link, and the vehicles of the different classes also follow FIFO in the queue area but not in the free flow area. To characterize this phenomenon by numerical methods, the improved model is directly formulated in discrete time space. Numerical examples are developed to illustrate the unrealistic flows of the existing model and the performance of the improved model. This analysis can more realistically capture the traffic flow propagation, such as interactions between multi-class traffic flows, and the dynamic traffic interactions across multiple links.

关键词： first-in-first-out (FIFO)     multi-class traffic     physical queues     traffic flow modeling    

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Traffic services for vehicles: the process from receiving raw probe data to space-time diagrams and theresulting traffic service

Markus AUER, Hubert REHBORN, Sven-Eric MOLZAHN, Micha KOLLER

《工程管理前沿（英文）》 2017年 第4卷 第4期   页码 490-497 doi: 10.15302/J-FEM-2017008

摘要： Today, large quantities of vehicle data (FCD: floating car data) are widely used by traffic service providers to create and broadcast traffic states in road networks. As a first processing step, all raw position data received from Global Positioning Systems (GPS) have to be map matched in a digital road map. The technical aspects of such a matching process for GPS data are described in this report. After the matching process, space-time-diagrams are created of the probe data showing traffic situation details over space and time. Various examples illustrate how traffic service quality depends on the number of matched GPS raw data; it will be stated that when 2% of connected vehicles in the total traffic flow are sending their GPS data in shorter time intervals, a high quality and precise reconstruction of the current traffic phases is achieved. Traffic reconstruction is followed by a translation into traffic information messages, which can be sent and used in vehicle navigation systems for driver information and dynamic route guidance.

关键词： floating car data     map matching     three phase traffic theory     traffic reconstruction     traffic service quality     navigation systems    

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Integrating storm surge modeling with traffic data analysis to evaluate the effectiveness of hurricane

《结构与土木工程前沿（英文）》 2021年 第15卷 第6期   页码 1301-1316 doi: 10.1007/s11709-021-0765-1

摘要： An integrated storm surge modeling and traffic analysis were conducted in this study to assess the effectiveness of hurricane evacuations through a case study of Hurricane Irma. The Category 5 hurricane in 2017 caused a record evacuation with an estimated 6.8 million people relocating statewide in Florida. The Advanced Circulation (ADCIRC) model was applied to simulate storm tides during the hurricane event. Model validations indicated that simulated pressures, winds, and storm surge compared well with observations. Model simulated storm tides and winds were used to estimate the area affected by Hurricane Irma. Results showed that the storm surge and strong wind mainly affected coastal counties in south-west Florida. Only moderate storm tides (maximum about 2.5 m) and maximum wind speed about 115 mph were shown in both model simulations and Federal Emergency Management Agency (FEMA) post-hurricane assessment near the area of hurricane landfall. Storm surges did not rise to the 100-year flood elevation level. The maximum wind was much below the design wind speed of 150–170 mph (Category 5) as defined in Florida Building Code (FBC) for south Florida coastal areas. Compared with the total population of about 2.25 million in the six coastal counties affected by storm surge and Category 1–3 wind, the statewide evacuation of approximately 6.8 million people was found to be an over-evacuation due mainly to the uncertainty of hurricane path, which shifted from south-east to south-west Florida. The uncertainty of hurricane tracks made it difficult to predict the appropriate storm surge inundation zone for evacuation. Traffic data were used to analyze the evacuation traffic patterns. In south-east Florida, evacuation traffic started 4 days before the hurricane’s arrival. However, the hurricane path shifted and eventually landed in south-west Florida, which caused a high level of evacuation traffic in south-west Florida. Over-evacuation caused Evacuation Traffic Index (ETI) to increase to 200% above normal conditions in some sections of highways, which reduced the effectiveness of evacuation. Results from this study show that evacuation efficiency can be improved in the future by more accurate hurricane forecasting, better public awareness of real-time storm surge and wind as well as integrated storm surge and evacuation modeling for quick response to the uncertainty of hurricane forecasting.

关键词： storm surge modeling     traffic     evacuation     Hurricane Irma    

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Percolation-based health management of complex traffic systems

《工程管理前沿（英文）》 2021年 第8卷 第4期   页码 557-571 doi: 10.1007/s42524-021-0174-0

摘要： System health management, which aims to ensure the safe and efficient operation of systems by reducing uncertain risks and cascading failures during their lifetime, is proposed for complex transportation systems and other critical infrastructures, especially under the background of the New Infrastructure Projects launched in China. Previous studies proposed numerous approaches to evaluate or improve traffic reliability or efficiency. Nevertheless, most existing studies neglected the core failure mechanism (i.e., spatio–temporal propagation of traffic congestion). In this article, we review existing studies on traffic reliability management and propose a health management framework covering the entire traffic congestion lifetime, from emergence, evolution to dissipation, based on the study of core failure modes with percolation theory. Aiming to be “reliable, invulnerable, resilient, potential, and active”, our proposed traffic health management framework includes modeling, evaluation, diagnosis, and improvement. Our proposed framework may shed light on traffic management for megacities and urban agglomerations around the world. This new approach may offer innovative insights for systems science and engineering in future intelligent infrastructure management.

关键词： traffic health     health management     critical infrastructure     systems science and engineering    

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Semantic Consistency and Correctness Verification of Digital Traffic Rules

Lei Wan,Changjun Wang,Daxin Luo,Hang Liu,Sha Ma,Weichao Hu,

《工程（英文）》 doi: 10.1016/j.eng.2023.04.016

摘要： The consensus of the automotive industry and traffic management authorities is that autonomous vehicles must follow the same traffic laws as human drivers. Using formal or digital methods, natural language traffic rules can be translated into machine language and used by autonomous vehicles. In this paper, a translation flow is designed. Beyond the translation, a deeper examination is required, because the semantics of natural languages are rich and complex, and frequently contain hidden assumptions. The issue of how to ensure that digital rules are accurate and consistent with the original intent of the traffic rules they represent is both significant and unresolved. In response, we propose a method of formal verification that combines equivalence verification with model checking. Reasonable and reassuring digital traffic rules can be obtained by utilizing the proposed traffic rule digitization flow and verification method. In addition, we offer a number of simulation applications that employ digital traffic rules to assess vehicle violations. The experimental findings indicate that our digital rules utilizing metric temporal logic (MTL) can be easily incorporated into simulation platforms and autonomous driving systems (ADS).

关键词： Autonomous driving     Traffic rules     Digitization     Formalization     Verification    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

《医学前沿（英文）》 doi: 10.1007/s11684-023-1050-6

摘要： Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challenge owing to scarce treatment alternatives. This review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiology, genomic characterization, risk factors, diagnosis, therapeutic strategies, and treatment resistance mechanisms. We delve into identifying risk factors, including genetic predisposition and environmental exposures, and explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancer. Additionally, we highlight the development and application of multi-omics approaches in pancreatic cancer research and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy. We also dissect the primary mechanisms underlying treatment resistance in this malignancy, illustrating the latest therapeutic options and advancements in the field. Conclusively, we accentuate the urgent demand for more extensive research to enhance the prognosis for pancreatic cancer patients.

关键词： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy resistance    

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基于本质安全的工业事故风险管理方法研究

吴宗之

《中国工程科学》 2007年 第9卷 第5期   页码 46-49

摘要：

从风险管理角度对生产过程中的安全防护方法进行了分类和论述，提出了基于本质安全思想的工业 事故综合风险管理方法与程序，其核心内容是在常规的危险辨识和风险评价基础上，优先应用本质安全原理来 减少、消除危险，综合采用无源安全措施、有源安全措施或多层安全防护措施与功能安全标准，将风险降低至 可接受水平；提出了本质安全应与清洁生产、绿色化学、循环经济同等纳入优先发展的技术和政策等建议。

关键词： 本质安全     风险管理     事故预防     安全设计    

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Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

《信息与电子工程前沿（英文）》 2015年 第16卷 第5期   页码 391-403 doi: 10.1631/FITEE.1400267

摘要： The continuous emerging of peer-to-peer (P2P) applications enriches resource sharing by networks, but it also brings about many challenges to network management. Therefore, P2P applications monitoring, in particular, P2P traffic classification, is becoming increasingly important. In this paper, we propose a novel approach for accurate P2P traffic classification at a fine-grained level. Our approach relies only on counting some special flows that are appearing frequently and steadily in the traffic generated by specific P2P applications. In contrast to existing methods, the main contribution of our approach can be summarized as the following two aspects. Firstly, it can achieve a high classification accuracy by exploiting only several generic properties of flows rather than complicated features and sophisticated techniques. Secondly, it can work well even if the classification target is running with other high bandwidth-consuming applications, outperforming most existing host-based approaches, which are incapable of dealing with this situation. We evaluated the performance of our approach on a real-world trace. Experimental results show that P2P applications can be classified with a true positive rate higher than 97.22% and a false positive rate lower than 2.78%.

关键词： Traffic classification     Peer-to-peer (P2P)     Fine-grained     Host-based    

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Evaluating the short-term effect of ambient temperature on non-fatal outdoor falls and road traffic injuries

《环境科学与工程前沿（英文）》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1705-1

摘要：

● A study assessing the temperature-injury relationship was conducted among students.

关键词： Ambient temperature     Fall     Road traffic injury     Student     China    

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Total phosphorus accident pollution and emergency response study based on geographic information system

Aifeng Zhai, Xiaowen Ding, Lin Liu, Quan Zhu, Guohe Huang

《环境科学与工程前沿（英文）》 2020年 第14卷 第3期 doi: 10.1007/s11783-020-1223-3

摘要： A new algorithm of two-dimensional water quantity and the quality model was built. The migration and diffusion of TP was simulated. The emergency measures for sudden water pollution accidents was proposed. In recent years, sudden water pollution accidents in China’s rivers have become more frequent, resulting in considerable effects on environmental safety. Therefore, it is necessary to simulate and predict pollution accidents. Simulation and prediction provide strong support for emergency disposal and disaster reduction. This paper describes a new two-dimensional water quantity and the quality model that incorporates a digital elevation model into the geographic information system. The model is used to simulate sudden water pollution accidents in the main stream of the Yangtze River and Jialing River in the Chongqing section of the Three Gorges Reservoir area. The sectional velocity distribution and concentration change of total phosphorus are then analyzed under four hydrological situations. The results show that the proposed model accurately simulates and predicts the concentration change and migration process of total phosphorus under sudden water pollution accidents. The speed of migration and diffusion of pollutants is found to be greatest in the flood season, followed by the water storage period, drawdown season, and dry season, in that order. The selection of an appropriate water scheduling scheme can reduce the peak concentration of river pollutants. This study enables the impact of pollutants on the ecological environment of river water to be alleviated, and provides a scientific basis for the emergency response to sudden water pollution accidents in the Three Gorges Reservoir area.

关键词： Sudden water pollution accident     Total phosphorus     Predictive model     Contaminant simulation     Water scheduling     Measure    

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安全理论基本假说

于海湧,李芳

《中国工程科学》 2006年 第8卷 第10期   页码 85-88

摘要：

通过大量事故案例及对现有安全理论的分析，将所有事故分为3类：自然事故、随机事故和人为事故，根据这3种事故的特点采用数学方程进行描述、量化，从数学模型角度论述事故发生的必然性、随机性和可预防性，以及不安全的绝对性和安全的相对性的辩证关系。同时根据数学模型提出了完整的、科学的事故预防基本对策。

关键词： 安全理论     事故类型     数学方程     事故预防    

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标题 作者 时间 类型 操作

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

期刊论文

Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

null

期刊论文

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

null

期刊论文

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

期刊论文

Multi-class dynamic network traffic flow propagation model with physical queues

Yanfeng LI, Jun LI

期刊论文

Traffic services for vehicles: the process from receiving raw probe data to space-time diagrams and theresulting traffic service

Markus AUER, Hubert REHBORN, Sven-Eric MOLZAHN, Micha KOLLER

期刊论文

Integrating storm surge modeling with traffic data analysis to evaluate the effectiveness of hurricane

期刊论文

Percolation-based health management of complex traffic systems

期刊论文

Semantic Consistency and Correctness Verification of Digital Traffic Rules

Lei Wan,Changjun Wang,Daxin Luo,Hang Liu,Sha Ma,Weichao Hu,

期刊论文

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

期刊论文

基于本质安全的工业事故风险管理方法研究

吴宗之

期刊论文

Fine-grained P2P traffic classification by simply counting flows

Jie HE,Yue-xiang YANG,Yong QIAO,Wen-ping DENG

期刊论文

Evaluating the short-term effect of ambient temperature on non-fatal outdoor falls and road traffic injuries

期刊论文

Total phosphorus accident pollution and emergency response study based on geographic information system

Aifeng Zhai, Xiaowen Ding, Lin Liu, Quan Zhu, Guohe Huang

期刊论文

安全理论基本假说

于海湧,李芳

期刊论文